The starting dosage is 12.5 milligrams once everyday or twice daily. The complete daily dosage could be increased in increments of 25 mg to 50 mg each day, if well-tolerated, to achieve a target dose of 300 milligrams to 450 mg every day (administered in separated dosages) by the end of 2 weeks. Consequently, the dose can be boosted once weekly or twice weekly, in increments of around 100 mg. The max dose is 900 milligrams daily. To lessen the risk of orthostatic hypotension, bradycardia, as well as syncope, it is essential to use this low beginning dose, steady titration timetable, and split dosages [see Precautions and warnings (5.

Typically, it is recommended that individuals responding to CLOZARIL proceed maintenance therapy on their reliable dosage beyond the severe episode.

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In case of planned termination of CLOZARIL treatment, lessen the dosage progressively over a duration of 1 to 2 weeks. If abrupt discontinuation is required (considering that of agranulocytosis or one more medical disorder, as an example), monitor thoroughly for the recurrence of psychotic signs and also symptoms associated with cholinergic rebound such as extreme sweating, migraine, nausea, vomiting, and also diarrhea.

When restarting CLOZARIL in clients which have ceased CLOZARIL (i. e. 2 days or more because the last dose), re-initiate with 12.5-mg daily or twice daily. This is essential to decrease the threat of syncope, hypotension, and also bradycardia [view Warnings and Precautions (5.3)] The dosage might be boosted to the previously restorative dose much more quickly than advised for preliminary therapy if that dose is well allowed.

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